Scientific

Publications

Virtual screening approach to identifying a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors

ACS Med. Chem. Lett. 2021, 12, 2, 217–227. doi: 10.1021/acsmedchemlett.0c00554

Leiris Simon, Davies David T., Sprynski Nicolas, Castandet Jérôme, Beyria Lilha , Bodnarchuk Michael S., Sutton Jonathan M., Mullins Toby M. G., Jones Mark W., Forrest Andrew K. , Pallin T. David, Karunakar Paduri, Martha Sathish Kumar, Parusharamulu Battu, Ramula Ramesh, Kotha Venkatesh, Pottabathini Narender, Pothukanuri Srinivasu, Lemonnier Marc, Everett Martin

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

Frontiers in Microbiology 2021, 11:620819. doi: 10.3389/fmicb.2020.620819

Cigana Cristina, Castandet Jérôme, Sprynski Nicolas, Melessike Medede, Beyria Lilha, Ranucci Serena, Alcalá-Franco Beatriz, Rossi Alice, Bragonzi Alessandra, Zalacain Magdalena, Everett Martin

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter Baumannii

Journal of Medicinal Chemistry, 63, 24, 15802–15820 (2020); DOI: 10.1021/acs.jmedchem.0c01535

David T. Davies, Simon Leiris, Magdalena Zalacain, Nicolas Sprynski, Jérôme Castandet, Justine Bousquet, Clarisse Lozano, Agustina Llanos, Laethitia Alibaud, Srinivas Vasa, Ramesh Pattipati, Ravindar Valige, Bhaskar Kummari, Srinivasu Pothukanuri, Cyntia De Piano, Ian Morrissey, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Giusy Tassone, Stefano Mangani, Jean-Denis Docquier, David Pallin, Richard Elliot, Marc Lemonnier, and Martin Everett

Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

Antimicrobial Agents and Chemotherapy 64, 11, (2020); DOI: 10.1128/AAC.01076-20

Shampa Das, Adam Johnson, Laura McEntee, Nicola Farrington, Adam Kirby, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Justine Bousquet, Laethitia Alibaud, Carole Sable, Magdalena Zalacain, Martin Everett, William Hope

ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae

ACS Infectious Diseases 6, 9, 2419–2430, (2020) ; DOI: 10.1021/acsinfecdis.0c00207

David T. Davies, Simon Leiris, Nicolas Sprynski, Jérôme Castandet, Clarisse Lozano, Justine Bousquet, Magdalena Zalacain, Srinivas Vasa, Praveen K. Dasari, Ramesh Pattipati, Naresh Vempala, Swetha Gujjewar, SyamKumar Godi, Raju Jallala, Rajashekar Reddy Sathyap, Narasimha A. Darshanoju, Vengala R. Ravu, Ramakrishna R. Juventhala, Narender Pottabathini, Somesh Sharma, Srinivasu Pothukanuri, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Jean-Denis Docquier, Marc Lemonnier, and Martin Everett

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-Lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

ACS Infectious Diseases 5, 1, 131‑140 (2019) ; DOI: 10.1021/acsinfecdis.8b00246

Simon Leiris, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Clarisse Lozano, Juliette Bougnon, Justine Bousquet, Martin Everett, Marc Lemonnier, Nicolas Sprynski, Magdalena Zalacain, Thomas David Pallin, Michael C. Cramp, Neil Jennings, Gilles Raphy, Mark W. Jones, Ramesh Pattipati, Battu Shankar, Relangi Sivasubrahmanyam, Ashok K. Soodhagani, Ramakrishna R. Juventhala, Narender Pottabathini, Srinivasu Pothukanuri, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Filomena De Luca, Giulia Cerboni, Jean-Denis Docquier, and David T. Davies

Discovery of a Novel Metallo b-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem- Resistant Enterobacteriacea

Antimicrobial Agents and Chemotherapy 62, 5, 11 (2018) ; DOI: 10.1128/AAC.00074-18

Martin Everett, Nicolas Sprynski, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Juliette Bougnon, Clarisse Lozano, David T. Davies, Simon Leiris, Magdalena Zalacain, Ian Morrissey, Sophie Magnet, Kirsty Holden, Peter Warn, Filomena De Luca, Jean-Denis Docquier, Marc Lemonnier

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