Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii
Antimicrob Agents Chemother (2024). doi.org/10.1128/aac.01120-23
Magdalena Zalacain, Pauline Achard, Agustina Llanos, Ian Morrissey, Stephen Hawser, Kirsty Holden, Eleanor Toomey, David Davies, Simon Leiris, Carole Sable, Adeline Ledoux, Justine Bousquet, Jérôme Castandet, Clarisse Lozano, Martin Everett, Marc Lemonnier.
Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients
Sci Rep 13, 14208 (2023). doi.org/10.1038/s41598-023-41333-9
Agustina Llanos, Pauline Achard, Justine Bousquet, Clarisse Lozano, Magdalena Zalacain, Carole Sable, Hélène Revillet, Marlène Murris, Marie Mittaine, Marc Lemonnier and Martin Everett.
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models
ACS Infect. Dis. 2023, 9, 2, 270–282. doi.org/10.1021/acsinfecdis.2c00418
Martin J. Everett, David T. Davies, Simon Leiris, Nicolas Sprynski, Agustina Llanos, Jérôme M. Castandet, Clarisse Lozano, Christopher N. LaRock, Doris L. LaRock, Giuseppina Corsica, Jean-Denis Docquier, Thomas D. Pallin, Andrew Cridland, Toby Blench, Magdalena Zalacain, and Marc Lemonnier.
Pseudomonas aeruginosa elastase (LasB) as a therapeutic target
Drug Discov Today 2021. doi: 10.1016/j.drudis.2021.02.026
Martin J Everett, David T Davies
Novel Specific Metallo-ß-lactamase Inhibitor, ANT2681, Restores Meropenem Activity to Clinically Effective Levels Against NDM-Positive Enterobacterales
Antimicrob Agents Chemother. 2021 Apr 5:AAC.00203-21. doi: 10.1128/AAC.00203-21
Magadalena Zalacain, Clarisse Lozano, Agustina Llanos, Nicolas Sprynski, Thomas Valmont, Cyntia De Piano, David Davies, Simon Leiris, Carole Sable, Adeline Ledoux, Ian Morrissey, Marc Lemonnier, Martin Everett
Designing Inhibitors of β‑Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria
Accounts of Chemical Research 2021, 54, 9, 2055–2064. doi: 10.1021/acs.accounts.0c00863
David T. Davies and Martin Everett
Virtual screening approach to identifying a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors
ACS Med. Chem. Lett. 2021, 12, 2, 217–227. doi: 10.1021/acsmedchemlett.0c00554
Leiris Simon, Davies David T., Sprynski Nicolas, Castandet Jérôme, Beyria Lilha , Bodnarchuk Michael S., Sutton Jonathan M., Mullins Toby M. G., Jones Mark W., Forrest Andrew K. , Pallin T. David, Karunakar Paduri, Martha Sathish Kumar, Parusharamulu Battu, Ramula Ramesh, Kotha Venkatesh, Pottabathini Narender, Pothukanuri Srinivasu, Lemonnier Marc, Everett Martin
Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model
Frontiers in Microbiology 2021, 11:620819. doi: 10.3389/fmicb.2020.620819
Cigana Cristina, Castandet Jérôme, Sprynski Nicolas, Melessike Medede, Beyria Lilha, Ranucci Serena, Alcalá-Franco Beatriz, Rossi Alice, Bragonzi Alessandra, Zalacain Magdalena, Everett Martin
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter Baumannii
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David T. Davies, Simon Leiris, Magdalena Zalacain, Nicolas Sprynski, Jérôme Castandet, Justine Bousquet, Clarisse Lozano, Agustina Llanos, Laethitia Alibaud, Srinivas Vasa, Ramesh Pattipati, Ravindar Valige, Bhaskar Kummari, Srinivasu Pothukanuri, Cyntia De Piano, Ian Morrissey, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Giusy Tassone, Stefano Mangani, Jean-Denis Docquier, David Pallin, Richard Elliot, Marc Lemonnier, and Martin Everett
Pharmacodynamics of the Novel Metallo-β-Lactamase Inhibitor ANT2681 in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae
Antimicrobial Agents and Chemotherapy 64, 11, (2020); DOI: 10.1128/AAC.01076-20
Shampa Das, Adam Johnson, Laura McEntee, Nicola Farrington, Adam Kirby, Jennifer Unsworth, Ana Jimenez-Valverde, Ruwanthi Kolamunnage-Dona, Justine Bousquet, Laethitia Alibaud, Carole Sable, Magdalena Zalacain, Martin Everett, William Hope
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae
ACS Infectious Diseases 6, 9, 2419–2430, (2020) ; DOI: 10.1021/acsinfecdis.0c00207
David T. Davies, Simon Leiris, Nicolas Sprynski, Jérôme Castandet, Clarisse Lozano, Justine Bousquet, Magdalena Zalacain, Srinivas Vasa, Praveen K. Dasari, Ramesh Pattipati, Naresh Vempala, Swetha Gujjewar, SyamKumar Godi, Raju Jallala, Rajashekar Reddy Sathyap, Narasimha A. Darshanoju, Vengala R. Ravu, Ramakrishna R. Juventhala, Narender Pottabathini, Somesh Sharma, Srinivasu Pothukanuri, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Jean-Denis Docquier, Marc Lemonnier, and Martin Everett
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-Lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model
ACS Infectious Diseases 5, 1, 131‑140 (2019) ; DOI: 10.1021/acsinfecdis.8b00246
Simon Leiris, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Clarisse Lozano, Juliette Bougnon, Justine Bousquet, Martin Everett, Marc Lemonnier, Nicolas Sprynski, Magdalena Zalacain, Thomas David Pallin, Michael C. Cramp, Neil Jennings, Gilles Raphy, Mark W. Jones, Ramesh Pattipati, Battu Shankar, Relangi Sivasubrahmanyam, Ashok K. Soodhagani, Ramakrishna R. Juventhala, Narender Pottabathini, Srinivasu Pothukanuri, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Filomena De Luca, Giulia Cerboni, Jean-Denis Docquier, and David T. Davies
Discovery of a Novel Metallo b-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem- Resistant Enterobacteriacea
Antimicrobial Agents and Chemotherapy 62, 5, 11 (2018) ; DOI: 10.1128/AAC.00074-18
Martin Everett, Nicolas Sprynski, Alicia Coelho, Jérôme Castandet, Maëlle Bayet, Juliette Bougnon, Clarisse Lozano, David T. Davies, Simon Leiris, Magdalena Zalacain, Ian Morrissey, Sophie Magnet, Kirsty Holden, Peter Warn, Filomena De Luca, Jean-Denis Docquier, Marc Lemonnier