Novel Specific Metallo-β-Lactamase Inhibitor, ANT2681, Restores meropenem Activity to Clinically Effective Levels Against NDM-Positive Enterobacterales

May 18, 2021

Magadalena Zalacain, Clarisse Lozano, Agustina Llanos, Nicolas Sprynski, Thomas Valmont, Cyntia De Piano, David Davies, Simon Leiris, Carole Sable, Adeline Ledoux, Ian Morrissey, Marc Lemonnier, Martin Everett

Designing Inhibitors of β-Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria

Mar 31, 2021

David T. Davies and Martin Everett

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

Jan 15, 2021

Leiris Simon, Davies David T., Sprynski Nicolas, Castandet Jérôme, Beyria Lilha , Bodnarchuk Michael S., Sutton Jonathan M., Mullins Toby M. G., Jones Mark W., Forrest Andrew K. , Pallin T. David, Karunakar Paduri, Martha Sathish Kumar, Parusharamulu Battu, Ramula...

Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model

Jan 12, 2021

Cigana Cristina, Castandet Jérôme, Sprynski Nicolas, Melessike Medede, Beyria Lilha, Ranucci Serena, Alcalá-Franco Beatriz, Rossi Alice, Bragonzi Alessandra, Zalacain Magdalena, Everett Martin

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates meropenem Activity Against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii ✔️ meropenem → lowercase (generic dr

Dec 11, 2020

David T. Davies, Simon Leiris, Magdalena Zalacain, Nicolas Sprynski, Jérôme Castandet, Justine Bousquet, Clarisse Lozano, Agustina Llanos, Laethitia Alibaud, Srinivas Vasa, Ramesh Pattipati, Ravindar Valige, Bhaskar Kummari, Srinivasu Pothukanuri, Cyntia De Piano, Ian...