Scientific publications
Disarming carbapenemase-producing Acinetobacter baumannii: high potency of the novel therapeutic combination of meropenem and the innovative diazabicyclooctane β-lactamase inhibitor pilabactam (formerly ANT3310)
Salud Rodríguez-Pallares, Michelle Outeda-García, Emilio Lence, Arianna Rodríguez-Coello, Lucía González-Pinto, Paula Guijarro-Sánchez, Gabriela A. Báez-Barroso, Tania Blanco-Martín, Juan C. Vázquez-Ucha, Agustina Llanos, Filomena Sannio, Jean-Denis Docquier, Ian Morrisey, Stephen Hawser, Magdalena Zalacain, Marc Lemonnier, Concepción González-Bello, Germán Bou, Alejandro Beceiro, Jorge Arca-Suárez
Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii
Magdalena Zalacain, Pauline Achard, Agustina Llanos, Ian Morrissey, Stephen Hawser, Kirsty Holden, Eleanor Toomey, David Davies, Simon Leiris, Carole Sable, Adeline Ledoux, Justine Bousquet, Jérôme Castandet, Clarisse Lozano, Martin Everett, Marc Lemonnier.
Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients
Agustina Llanos, Pauline Achard, Justine Bousquet, Clarisse Lozano, Magdalena Zalacain, Carole Sable, Hélène Revillet, Marlène Murris, Marie Mittaine, Marc Lemonnier and Martin Everett.
Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models
Martin J. Everett, David T. Davies, Simon Leiris, Nicolas Sprynski, Agustina Llanos, Jérôme M. Castandet, Clarisse Lozano, Christopher N. LaRock, Doris L. LaRock, Giuseppina Corsica, Jean-Denis Docquier, Thomas D. Pallin, Andrew Cridland, Toby Blench, Magdalena Zalacain, and Marc Lemonnier.
Pseudomonas aeruginosa elastase (LasB) as a therapeutic target
Martin J Everett, David T Davies
Novel Specific Metallo-ß-lactamase Inhibitor, ANT2681, Restores Meropenem Activity to Clinically Effective Levels Against NDM-Positive Enterobacterales
Magadalena Zalacain, Clarisse Lozano, Agustina Llanos, Nicolas Sprynski, Thomas Valmont, Cyntia De Piano, David Davies, Simon Leiris, Carole Sable, Adeline Ledoux, Ian Morrissey, Marc Lemonnier, Martin Everett
Designing Inhibitors of β‑Lactamase Enzymes to Overcome Carbapenem Resistance in Gram-Negative Bacteria
David T. Davies and Martin Everett
Virtual screening approach to identifying a novel and tractable series of Pseudomonas aeruginosa elastase inhibitors
Leiris Simon, Davies David T., Sprynski Nicolas, Castandet Jérôme, Beyria Lilha , Bodnarchuk Michael S., Sutton Jonathan M., Mullins Toby M. G., Jones Mark W., Forrest Andrew K. , Pallin T. David, Karunakar Paduri, Martha Sathish Kumar, Parusharamulu Battu, Ramula Ramesh, Kotha Venkatesh, Pottabathini Narender, Pothukanuri Srinivasu, Lemonnier Marc, Everett Martin
Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model
Cigana Cristina, Castandet Jérôme, Sprynski Nicolas, Melessike Medede, Beyria Lilha, Ranucci Serena, Alcalá-Franco Beatriz, Rossi Alice, Bragonzi Alessandra, Zalacain Magdalena, Everett Martin