Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

Martin J. Everett, David T. Davies, Simon Leiris, Nicolas Sprynski, Agustina Llanos, Jérôme M. Castandet, Clarisse Lozano, Christopher N. LaRock, Doris L. LaRock, Giuseppina Corsica, Jean-Denis Docquier, Thomas D. Pallin, Andrew Cridland, Toby Blench, Magdalena Zalacain, and Marc Lemonnier.